A man is tasked with driving his embittered 80-year-old father-in-law cross country to be legally euthanized in Oregon, while along the way helping him rediscover a reason for living.

Annie and Baxter, the adult children of the controversial husband and wife conceptual performance art couple famous for their quirky macabre public performances, have never got over the fact that their parents kept using them during their childhood in their often gory and disturbing satirical public performances. They often clash with their now elderly parents over this and blame them for their problems in their adult life. However, the two become worried when they're told by the police that their parents have gone missing during their trip outside of town. The brother considers the possibility that something horrible might have happened to them, but the sister is convinced that it's just another one of their stupid games or twisted conceptual performances. She convinces him that they should go and look for them themselves.

A former high school football star and one time college athlete, Jon has landed back in the place of his youth -- Fairhaven -- a small fishing village on the Massachusetts coast. Now in his early thirties, and with the promise of younger days seemingly washed ashore, Jon's vague feelings of dissatisfaction are crystallized by a television interview with his football hero Tom Brady, who proclaims that, even after three super bowl wins, "There's got to be something more than this." Jon recounts his epiphany to Sam, old friend and schoolmate who married early, fathered early, divorced early and never left town. Sam made his own peace with small town life years ago, and is happy enough just to provide a stable home for his loving daughter, Cara, while secretly still pining for his beautiful ex-wife Kate. Together, Jon and Sam anticipate the return of Dave, the third member of their once-indomitable trio. Having left town seven years ago and never looked back, Dave is finally returning to ...